Cargando…

Abnormalities of DYRK1A-Cytoskeleton Complexes in the Blood Cells as Potential Biomarkers of Alzheimer’s Disease

BACKGROUND: DYRK1A is implicated in mental retardation and Alzheimer’s disease (AD) dementia of Down syndrome (DS) individuals. The protein is associated with cytoskeleton and altered expression has been shown to impair the cytoskeletal network via dosage effect. OBJECTIVE: Our original observations...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dowjat, Karol, Adayev, Tatyana, Wojda, Urszula, Brzozowska, Katarzyna, Barczak, Anna, Gabryelewicz, Tomasz, Hwang, Yu-Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971831/ https://www.ncbi.nlm.nih.gov/pubmed/31683476 http://dx.doi.org/10.3233/JAD-190475

Ejemplares similares

An ELISA DYRK1A non-radioactive kinase assay suitable for the characterization of inhibitors
por: Liu, Yong, et al.
Publicado: (2017)

Optimized RT-qPCR and a novel normalization method for validating circulating miRNA biomarkers in ageing-related diseases
por: Want, Andrew, et al.
Publicado: (2023)

Profile of 6 microRNA in blood plasma distinguish early stage Alzheimer’s disease patients from non-demented subjects
por: Nagaraj, Siranjeevi, et al.
Publicado: (2017)

T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers
por: Mietelska-Porowska, Anna, et al.
Publicado: (2017)

Oxidant/Antioxidant Imbalance in Alzheimer's Disease: Therapeutic and Diagnostic Prospects
por: Wojsiat, Joanna, et al.
Publicado: (2018)

Candidate Alzheimer’s Disease Biomarker miR-483-5p Lowers TAU Phosphorylation by Direct ERK1/2 Repression
por: Nagaraj, Siranjeevi, et al.
Publicado: (2021)

Dyrk1 inhibition improves Alzheimer's disease‐like pathology
por: Branca, Caterina, et al.
Publicado: (2017)

Plasma DYRK1A as a novel risk factor for Alzheimer's disease
por: Janel, N, et al.
Publicado: (2014)

Antisense oligonucleotides for Alzheimer's disease therapy: from the mRNA to miRNA paradigm
por: Grabowska-Pyrzewicz, Wioleta, et al.
Publicado: (2021)

Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A
por: Widowati, Esti Wahyu, et al.
Publicado: (2018)

Urolithin A exhibits a neuroprotective effect against Alzheimer’s disease by inhibiting DYRK1A activity
por: Tu, Huang-Ju, et al.
Publicado: (2023)

Clinical course of epilepsy and white matter abnormality linked to a novel DYRK1A variant
por: Okazaki, Tetsuya, et al.
Publicado: (2021)

DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B
por: Yousefelahiyeh, Mina, et al.
Publicado: (2018)

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B
por: Papenfuss, Marco, et al.
Publicado: (2022)

Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer’s disease
por: Janel, N, et al.
Publicado: (2017)

Emerging roles of DYRK2 in cancer
por: Tandon, Vasudha, et al.
Publicado: (2021)

DYRK1A genetic variants are not linked to Alzheimer's disease in a Spanish case-control cohort
por: Vázquez-Higuera, José Luis, et al.
Publicado: (2009)

DYRK1a Inhibitor Mediated Rescue of Drosophila Models of Alzheimer’s Disease-Down Syndrome Phenotypes
por: Zhu, Bangfu, et al.
Publicado: (2022)

Corrosion Assessment of a Weathering Steel Bridge Structure after 30 Years of Service
por: Królikowska, Agnieszka, et al.
Publicado: (2021)

The Omnipresence of DYRK1A in Human Diseases
por: Deboever, Estelle, et al.
Publicado: (2022)

Induction of Brain Insulin Resistance and Alzheimer’s Molecular Changes by Western Diet
por: Mietelska-Porowska, Anna, et al.
Publicado: (2022)

Familial Alzheimer’s Disease Lymphocytes Respond Differently Than Sporadic Cells to Oxidative Stress: Upregulated p53-p21 Signaling Linked with Presenilin 1 Mutants
por: Wojsiat, Joanna, et al.
Publicado: (2016)

Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease
por: Wiȩckowska-Gacek, Angelika, et al.
Publicado: (2021)

The Cytoskeleton—A Complex Interacting Meshwork
por: Hohmann, Tim, et al.
Publicado: (2019)

Dynamics of the Actin Cytoskeleton at Adhesion Complexes
por: Cronin, Nicholas M., et al.
Publicado: (2021)

Mirk/dyrk1B Kinase in Ovarian Cancer
por: Friedman, Eileen
Publicado: (2013)

Ocular Phenotype Associated with DYRK1A Variants
por: Méjécase, Cécile, et al.
Publicado: (2021)

Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors
por: Henderson, Scott H., et al.
Publicado: (2021)

Functional Roles of DYRK2 as a Tumor Regulator
por: Mochimaru, Yuta, et al.
Publicado: (2023)

A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay
por: Lee, Kyu-Sun, et al.
Publicado: (2020)

DYRK1A antagonists rescue degeneration and behavioural deficits of in vivo models based on amyloid-β, Tau and DYRK1A neurotoxicity
por: Zhu, Bangfu, et al.
Publicado: (2022)

Sequential phosphorylation of NDEL1 by the DYRK2-GSK3β complex is critical for neuronal morphogenesis
por: Woo, Youngsik, et al.
Publicado: (2019)

DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis
por: Barzowska, Agata, et al.
Publicado: (2021)

Linker of nucleoskeleton and cytoskeleton complex proteins in cardiomyopathy
por: Stroud, Matthew J.
Publicado: (2018)

β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites
por: Frost, Danielle, et al.
Publicado: (2011)

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice
por: Souchet, Benoît, et al.
Publicado: (2019)

Disruption of DYRK1A-induced hyperphosphorylation of amyloid-beta and tau protein in Alzheimer’s disease: An integrative molecular modeling approach
por: Shukla, Rohit, et al.
Publicado: (2023)

Detection and Quantification of the Fragile X Mental Retardation Protein 1 (FMRP)
por: LaFauci, Giuseppe, et al.
Publicado: (2016)

CEP97 phosphorylation by Dyrk1a is critical for centriole separation during multiciliogenesis
por: Lee, Moonsup, et al.
Publicado: (2021)

Identification of Suppressors of mbk-2/DYRK by Whole-Genome Sequencing
por: Wang, Yuemeng, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_gcav5g110v77970nkd79bjbs17