Cargando…

TSPO Ligands Boost Mitochondrial Function and Pregnenolone Synthesis

Translocator protein 18 kDa (TSPO) is located in the mitochondrial outer membrane and plays an important role in steroidogenesis and cell survival. In the central nervous system (CNS), its expression is upregulated in neuropathologies such as Alzheimer’s disease (AD). Previously, we demonstrated th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lejri, Imane, Grimm, Amandine, Hallé, François, Abarghaz, Mustapha, Klein, Christian, Maitre, Michel, Schmitt, Martine, Bourguignon, Jean-Jacques, Mensah-Nyagan, Ayikoe Guy, Bihel, Frederic, Eckert, Anne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6971832/ https://www.ncbi.nlm.nih.gov/pubmed/31256132 http://dx.doi.org/10.3233/JAD-190127

Ejemplares similares

Mitochondria modulatory effects of new TSPO ligands in a cellular model of tauopathies
por: Grimm, Amandine, et al.
Publicado: (2019)

Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis
por: Witzig, Melissa, et al.
Publicado: (2020)

Alzheimer's Disease, Oestrogen and Mitochondria: an Ambiguous Relationship
por: Grimm, Amandine, et al.
Publicado: (2012)

Xanthurenic Acid Binds to Neuronal G-Protein-Coupled Receptors That Secondarily Activate Cationic Channels in the Cell Line NCB-20
por: Taleb, Omar, et al.
Publicado: (2012)

Sex hormone-related neurosteroids differentially rescue bioenergetic deficits induced by amyloid-β or hyperphosphorylated tau protein
por: Grimm, Amandine, et al.
Publicado: (2015)

Mitochondria, Estrogen and Female Brain Aging
por: Lejri, Imane, et al.
Publicado: (2018)

Ginkgo biloba extract increases neurite outgrowth and activates the Akt/mTOR pathway
por: Lejri, Imane, et al.
Publicado: (2019)

A proposed preventive role for Gamma-hydroxybutyrate (Xyrem(R)) in Alzheimer’s disease
por: Maitre, Michel, et al.
Publicado: (2016)

A Role for Xanthurenic Acid in the Control of Brain Dopaminergic Activity
por: Taleb, Omar, et al.
Publicado: (2021)

Mitochondria- and Oxidative Stress-Targeting Substances in Cognitive Decline-Related Disorders: From Molecular Mechanisms to Clinical Evidence
por: Lejri, Imane, et al.
Publicado: (2019)

Rhodiola Rosea Extract Counteracts Stress in an Adaptogenic Response Curve Manner via Elimination of ROS and Induction of Neurite Outgrowth
por: Agapouda, Anastasia, et al.
Publicado: (2022)

Inhibition of the Mitochondrial Enzyme ABAD Restores the Amyloid-β-Mediated Deregulation of Estradiol
por: Lim, Yun-An, et al.
Publicado: (2011)

Spermidine Rescues Bioenergetic and Mitophagy Deficits Induced by Disease-Associated Tau Protein
por: Fairley, Lauren H., et al.
Publicado: (2023)

5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease
por: Klein, Christian, et al.
Publicado: (2018)

Myelin in Alzheimer’s disease: culprit or bystander?
por: Maitre, Michel, et al.
Publicado: (2023)

Comparative Analysis of Gelsemine and Gelsemium sempervirens Activity on Neurosteroid Allopregnanolone Formation in the Spinal Cord and Limbic System
por: Venard, Christine, et al.
Publicado: (2011)

Neurosteroid 3α-Androstanediol Efficiently Counteracts Paclitaxel-Induced Peripheral Neuropathy and Painful Symptoms
por: Meyer, Laurence, et al.
Publicado: (2013)

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood
por: Marginedas-Freixa, I., et al.
Publicado: (2016)

Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand
por: Harteneck, Christian
Publicado: (2013)

Social Isolation in Early versus Late Adolescent Mice Is Associated with Persistent Behavioral Deficits That Can Be Improved by Neurosteroid-Based Treatment
por: Locci, Andrea, et al.
Publicado: (2017)

Proceedings: Pregnenolone metabolism in patients with carcinoma.
por: O'Higgins, N., et al.
Publicado: (1974)

FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis
por: Kremer, Laurent, et al.
Publicado: (2019)

Therapeutic potential of pregnenolone and pregnenolone methyl ether on depressive and CDKL5 deficiency disorders: Focus on microtubule targeting
por: Barbiero, Isabella, et al.
Publicado: (2021)

H1153Y-KCNH2 Mutation Identified in a Sudden Arrhythmic Death Syndrome Case Alters Channel Gating
por: Farrugia, Audrey, et al.
Publicado: (2021)

Induction of ATP Release, PPIX Transport, and Cholesterol Uptake by Human Red Blood Cells Using a New Family of TSPO Ligands
por: Marginedas-Freixa, Irene, et al.
Publicado: (2018)

Microglial Cell Morphology and Phagocytic Activity Are Critically Regulated by the Neurosteroid Allopregnanolone: A Possible Role in Neuroprotection
por: Jolivel, Valérie, et al.
Publicado: (2021)

Tetrapyrroles as Endogenous TSPO Ligands in Eukaryotes and Prokaryotes: Comparisons with Synthetic Ligands
por: Veenman, Leo, et al.
Publicado: (2016)

Reduction of Traumatic Brain Damage by Tspo Ligand Etifoxine
por: Shehadeh, Mona, et al.
Publicado: (2019)

Rapid Discrimination of Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis Using Machine Learning on Infrared Spectra of Sera
por: El Khoury, Youssef, et al.
Publicado: (2022)

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis
por: Collongues, Nicolas, et al.
Publicado: (2022)

Classical and Novel TSPO Ligands for the Mitochondrial TSPO Can Modulate Nuclear Gene Expression: Implications for Mitochondrial Retrograde Signaling
por: Yasin, Nasra, et al.
Publicado: (2017)

Alterations in Pregnenolone and Testosterone Levels in Male Shift Workers
por: Bracci, Massimo, et al.
Publicado: (2023)

Astrocytes and neurosteroids: metabolism of pregnenolone and dehydroepiandrosterone. Regulation by cell density
Publicado: (1993)

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone
por: Majeed, Yasser, et al.
Publicado: (2012)

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
por: Ramírez, Sara, et al.
Publicado: (2022)

A TSPO ligand is protective in a mouse model of multiple sclerosis
por: Daugherty, Daniel J, et al.
Publicado: (2013)

TSPO PIGA Ligands Promote Neurosteroidogenesis and Human Astrocyte Well-Being
por: Da Pozzo, Eleonora, et al.
Publicado: (2016)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Determination and reduction of translocator protein (TSPO) ligand rs6971 discrimination
por: Sokias, Renee, et al.
Publicado: (2016)

A TSPO ligand attenuates brain injury after intracerebral hemorrhage
por: Li, Minshu, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_4ac34ad0hfhs5dca7ll070lh03