Clinical implications of the oncometabolite succinate in SDHx‐mutation carriers

Succinate dehydrogenase (SDH) mutations lead to the accumulation of succinate, which acts as an oncometabolite. Germline SDHx mutations predispose to paraganglioma (PGL) and pheochromocytoma (PCC), as well as to renal cell carcinoma and gastro‐intestinal stromal tumors. The SDHx genes were the first...

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Detalles Bibliográficos
Autores principales: Eijkelenkamp, Karin, Osinga, Thamara E., Links, Thera P., van der Horst‐Schrivers, Anouk N.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2019
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972524/
https://www.ncbi.nlm.nih.gov/pubmed/30977114
http://dx.doi.org/10.1111/cge.13553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972524/
https://www.ncbi.nlm.nih.gov/pubmed/30977114
http://dx.doi.org/10.1111/cge.13553

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