Effects of Upadacitinib Coadministration on the Pharmacokinetics of Sensitive Cytochrome P450 Probe Substrates: A Study With the Modified Cooperstown 5+1 Cocktail

The aim of this study was to characterize the effects of upadacitinib, a Janus kinase 1 inhibitor, on in vivo activity of different cytochrome P450 (CYP) enzymes using a cocktail approach. Healthy subjects (n = 20) received single oral doses of the modified Cooperstown 5+1 cocktail drugs (midazolam...

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Detalles Bibliográficos
Autores principales: Mohamed, Mohamed‐Eslam F., Feng, Tian, Enejosa, Jeffrey V., Fisniku, Ogert, Othman, Ahmed A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Drug Interactions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972567/
https://www.ncbi.nlm.nih.gov/pubmed/31378969
http://dx.doi.org/10.1002/jcph.1496

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972567/
https://www.ncbi.nlm.nih.gov/pubmed/31378969
http://dx.doi.org/10.1002/jcph.1496

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