A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates

A photolabile carba(dethia) malonyl N‐acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation. From the lasalocid A polyketide assembly in a mutant strain of the soil bacterium Streptomyces lasaliensis, a previously un...

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Detalles Bibliográficos
Autores principales: Kilgour, Samantha L., Jenkins, Robert, Tosin, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972646/
https://www.ncbi.nlm.nih.gov/pubmed/31617624
http://dx.doi.org/10.1002/chem.201903661
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author Kilgour, Samantha L.
Jenkins, Robert
Tosin, Manuela
author_facet Kilgour, Samantha L.
Jenkins, Robert
Tosin, Manuela
author_sort Kilgour, Samantha L.
collection PubMed
description A photolabile carba(dethia) malonyl N‐acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation. From the lasalocid A polyketide assembly in a mutant strain of the soil bacterium Streptomyces lasaliensis, a previously undetected cyclised intermediate was identified and characterised, providing a new outlook on the timing of substrate processing.
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spelling pubmed-69726462020-01-27 A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates Kilgour, Samantha L. Jenkins, Robert Tosin, Manuela Chemistry Communications A photolabile carba(dethia) malonyl N‐acetylcysteamine derivative was devised and prepared for the trapping of biosynthetic polyketide intermediates following light activation. From the lasalocid A polyketide assembly in a mutant strain of the soil bacterium Streptomyces lasaliensis, a previously undetected cyclised intermediate was identified and characterised, providing a new outlook on the timing of substrate processing. John Wiley and Sons Inc. 2019-11-28 2019-12-20 /pmc/articles/PMC6972646/ /pubmed/31617624 http://dx.doi.org/10.1002/chem.201903661 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Kilgour, Samantha L.
Jenkins, Robert
Tosin, Manuela
A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates
title A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates
title_full A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates
title_fullStr A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates
title_full_unstemmed A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates
title_short A Photoactivatable Small‐Molecule Probe for the In Vivo Capture of Polyketide Intermediates
title_sort photoactivatable small‐molecule probe for the in vivo capture of polyketide intermediates
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972646/
https://www.ncbi.nlm.nih.gov/pubmed/31617624
http://dx.doi.org/10.1002/chem.201903661
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