Deoxyguanosine is a TLR7 agonist

Toll‐like receptor 7 (TLR7) is an innate immune sensor for single‐strand RNA (ssRNA). Recent structural analysis revealed that TLR7 has an additional binding site for nucleosides such as guanosine, and is activated when both guanosine and ssRNA bind. The nucleoside binding site also accommodates imi...

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Detalles Bibliográficos
Autores principales: Davenne, Tamara, Bridgeman, Anne, Rigby, Rachel E., Rehwinkel, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Innate immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972671/
https://www.ncbi.nlm.nih.gov/pubmed/31608988
http://dx.doi.org/10.1002/eji.201948151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972671/
https://www.ncbi.nlm.nih.gov/pubmed/31608988
http://dx.doi.org/10.1002/eji.201948151

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