Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms

Although fibroblast heterogeneity is recognized in primary tumors, both its characterization in and its impact on metastases remain unknown. Here, combining flow cytometry, immunohistochemistry and RNA-sequencing on breast cancer samples, we identify four Cancer-Associated Fibroblast (CAF) subpopula...

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Detalles Bibliográficos
Autores principales: Pelon, Floriane, Bourachot, Brigitte, Kieffer, Yann, Magagna, Ilaria, Mermet-Meillon, Fanny, Bonnet, Isabelle, Costa, Ana, Givel, Anne-Marie, Attieh, Youmna, Barbazan, Jorge, Bonneau, Claire, Fuhrmann, Laetitia, Descroix, Stéphanie, Vignjevic, Danijela, Silberzan, Pascal, Parrini, Maria Carla, Vincent-Salomon, Anne, Mechta-Grigoriou, Fatima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972713/
https://www.ncbi.nlm.nih.gov/pubmed/31964880
http://dx.doi.org/10.1038/s41467-019-14134-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972713/
https://www.ncbi.nlm.nih.gov/pubmed/31964880
http://dx.doi.org/10.1038/s41467-019-14134-w

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