CR6-interacting factor 1 deficiency reduces endothelial nitric oxide synthase activity by inhibiting biosynthesis of tetrahydrobiopterin

Downregulation of CR6 interacting factor 1 (CRIF1) has been reported to induce mitochondrial dysfunction, resulting in reduced activity of endothelial nitric oxide synthase (eNOS) and NO production in endothelial cells. Tetrahydrobiopterin (BH4) is an important cofactor in regulating the balance bet...

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Detalles Bibliográficos
Autores principales: Lee, Ikjun, Kim, Seonhee, Nagar, Harsha, Choi, Su-jeong, Jeon, Byeong Hwa, Piao, Shuyu, Kim, Cuk-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972730/
https://www.ncbi.nlm.nih.gov/pubmed/31964986
http://dx.doi.org/10.1038/s41598-020-57673-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972730/
https://www.ncbi.nlm.nih.gov/pubmed/31964986
http://dx.doi.org/10.1038/s41598-020-57673-9

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