Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice

Hyperuricemia drives the development of nonalcoholic fatty liver disease (NAFLD). Pharmacological inhibition of xanthine oxidase (XO), a rate-limiting enzyme for uric acid (UA) production, has been demonstrated to improve hepatic steatosis in diet-induced obese mice. However, it remains unclear whet...

Descripción completa

Detalles Bibliográficos
Autores principales: Nishikawa, Tomoki, Nagata, Naoto, Shimakami, Tetsuro, Shirakura, Takashi, Matsui, Chieko, Ni, Yinhua, Zhuge, Fen, Xu, Liang, Chen, Guanliang, Nagashimada, Mayumi, Yamashita, Taro, Sakai, Yoshio, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Kaneko, Shuichi, Ota, Tsuguhito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972756/
https://www.ncbi.nlm.nih.gov/pubmed/31965018
http://dx.doi.org/10.1038/s41598-020-57784-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972756/
https://www.ncbi.nlm.nih.gov/pubmed/31965018
http://dx.doi.org/10.1038/s41598-020-57784-3

Ejemplares similares