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Development of a cognitive function marker based on D-amino acid proportions using new chiral tandem LC-MS/MS systems
The incidence of dementia, a clinical symptom characterized by severe cognitive decline, is increasing worldwide. Predictive biomarkers are therefore required for early identification and management. D-amino acids in the brain contribute to cognitive function and are suggested as useful biomarkers f...
Autores principales: | Kimura, Ren, Tsujimura, Hisashi, Tsuchiya, Masaru, Soga, Satoko, Ota, Noriyasu, Tanaka, Atsushi, Kim, Hunkyung |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972825/ https://www.ncbi.nlm.nih.gov/pubmed/31965028 http://dx.doi.org/10.1038/s41598-020-57878-y |
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