Pharmacological enrichment of polygenic risk for precision medicine in complex disorders

Individuals with complex disorders typically have a heritable burden of common variation that can be expressed as a polygenic risk score (PRS). While PRS has some predictive utility, it lacks the molecular specificity to be directly informative for clinical interventions. We therefore sought to deve...

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Detalles Bibliográficos
Autores principales: Reay, William R., Atkins, Joshua R., Carr, Vaughan J., Green, Melissa J., Cairns, Murray J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972917/
https://www.ncbi.nlm.nih.gov/pubmed/31964963
http://dx.doi.org/10.1038/s41598-020-57795-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972917/
https://www.ncbi.nlm.nih.gov/pubmed/31964963
http://dx.doi.org/10.1038/s41598-020-57795-0

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