Structure-guided design of pure orthosteric inhibitors of αIIbβ3 that prevent thrombosis but preserve hemostasis

A prevailing dogma is that inhibition of vascular thrombosis by antagonizing platelet integrin αIIbβ3 cannot be achieved without compromising hemostasis, thus causing serious bleeding and increased morbidity and mortality. It is speculated that these adverse outcomes result from drug-induced activat...

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Detalles Bibliográficos
Autores principales: Adair, Brian D., Alonso, José L., van Agthoven, Johannes, Hayes, Vincent, Ahn, Hyun Sook, Yu, I-Shing, Lin, Shu-Wha, Xiong, Jian-Ping, Poncz, Mortimer, Arnaout, M. Amin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972956/
https://www.ncbi.nlm.nih.gov/pubmed/31964886
http://dx.doi.org/10.1038/s41467-019-13928-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972956/
https://www.ncbi.nlm.nih.gov/pubmed/31964886
http://dx.doi.org/10.1038/s41467-019-13928-2

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