A novel microchip‐based imaged CIEF‐MS system for comprehensive characterization and identification of biopharmaceutical charge variants

A microfluidic system has been designed that integrates both imaged capillary isoelectric focusing (iCIEF) separations and downstream MS detection into a single assay. Along with the construction of novel instrumentation and an innovative microfluidic chip, conversion to MS‐compatible separation rea...

Descripción completa

Detalles Bibliográficos
Autores principales: Mack, Scott, Arnold, Don, Bogdan, Greg, Bousse, Luc, Danan, Lieza, Dolnik, Vladislav, Ducusin, MaryAnn, Gwerder, Eric, Herring, Chris, Jensen, Morten, Ji, Jennifer, Lacy, Steve, Richter, Claudia, Walton, Ian, Gentalen, Erik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Bioseparations 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972975/
https://www.ncbi.nlm.nih.gov/pubmed/31663138
http://dx.doi.org/10.1002/elps.201900325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972975/
https://www.ncbi.nlm.nih.gov/pubmed/31663138
http://dx.doi.org/10.1002/elps.201900325

Ejemplares similares