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Patisiran Pharmacokinetics, Pharmacodynamics, and Exposure‐Response Analyses in the Phase 3 APOLLO Trial in Patients With Hereditary Transthyretin‐Mediated (hATTR) Amyloidosis

Hereditary transthyretin‐mediated (hATTR) amyloidosis is an inherited, rapidly progressive, life‐threatening disease caused by deposition of abnormal transthyretin protein. Patisiran is an RNA interference therapeutic comprising a novel, small interfering ribonucleic acid (ALN‐18328) formulated in a...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaoping, Goel, Varun, Attarwala, Husain, Sweetser, Marianne T., Clausen, Valerie A., Robbie, Gabriel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972979/
https://www.ncbi.nlm.nih.gov/pubmed/31322739
http://dx.doi.org/10.1002/jcph.1480