Covalent‐Allosteric Inhibitors to Achieve Akt Isoform‐Selectivity

Isoforms of protein kinase Akt are involved in essential processes including cell proliferation, survival, and metabolism. However, their individual roles in health and disease have not been thoroughly evaluated. Thus, there is an urgent need for perturbation studies, preferably mediated by highly s...

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Detalles Bibliográficos
Autores principales: Quambusch, Lena, Landel, Ina, Depta, Laura, Weisner, Jörn, Uhlenbrock, Niklas, Müller, Matthias P., Glanemann, Franziska, Althoff, Kristina, Siveke, Jens T., Rauh, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972997/
https://www.ncbi.nlm.nih.gov/pubmed/31584233
http://dx.doi.org/10.1002/anie.201909857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972997/
https://www.ncbi.nlm.nih.gov/pubmed/31584233
http://dx.doi.org/10.1002/anie.201909857

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