High‐throughput compound screen reveals mTOR inhibitors as potential therapeutics to reduce (auto)antibody production by human plasma cells

Antibody production by the B cell compartment is a crucial part of the adaptive immune response. Dysregulated antibody production in the form of autoantibodies can cause autoimmune disease. To date, B‐cell depletion with anti‐CD20 antibodies is commonly applied in autoimmunity, but pre‐existing plas...

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Detalles Bibliográficos
Autores principales: Tuijnenburg, Paul, aan de Kerk, Daan J., Jansen, Machiel H., Morris, Ben, Lieftink, Cor, Beijersbergen, Roderick L., van Leeuwen, Ester M.M., Kuijpers, Taco W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Adaptive immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972998/
https://www.ncbi.nlm.nih.gov/pubmed/31621069
http://dx.doi.org/10.1002/eji.201948241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6972998/
https://www.ncbi.nlm.nih.gov/pubmed/31621069
http://dx.doi.org/10.1002/eji.201948241

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