Stafia‐1: a STAT5a‐Selective Inhibitor Developed via Docking‐Based Screening of in Silico O‐Phosphorylated Fragments

We present a new approach for the identification of inhibitors of phosphorylation‐dependent protein–protein interaction domains, in which phenolic fragments are adapted by in silico O‐phosphorylation before docking‐based screening. From a database of 10 369 180 compounds, we identified 85 021 natura...

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Detalles Bibliográficos
Autores principales: Natarajan, Kalaiselvi, Müller‐Klieser, Daniel, Rubner, Stefan, Berg, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973011/
https://www.ncbi.nlm.nih.gov/pubmed/31503360
http://dx.doi.org/10.1002/chem.201904147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973011/
https://www.ncbi.nlm.nih.gov/pubmed/31503360
http://dx.doi.org/10.1002/chem.201904147

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