Cargando…

Sugar Puckering Drives G‐Quadruplex Refolding: Implications for V‐Shaped Loops

A DNA G‐quadruplex adopting a (3+1) hybrid structure was modified in two adjacent syn positions of the antiparallel strand with anti‐favoring 2′‐deoxy‐2′‐fluoro‐riboguanosine ((F)rG) analogues. The two substitutions promoted a structural rearrangement to a topology with the 5′‐terminal G residue loc...

Descripción completa

Detalles Bibliográficos
Autores principales: Haase, Linn, Dickerhoff, Jonathan, Weisz, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973071/
https://www.ncbi.nlm.nih.gov/pubmed/31609483
http://dx.doi.org/10.1002/chem.201904044