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Sugar Puckering Drives G‐Quadruplex Refolding: Implications for V‐Shaped Loops
A DNA G‐quadruplex adopting a (3+1) hybrid structure was modified in two adjacent syn positions of the antiparallel strand with anti‐favoring 2′‐deoxy‐2′‐fluoro‐riboguanosine ((F)rG) analogues. The two substitutions promoted a structural rearrangement to a topology with the 5′‐terminal G residue loc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973071/ https://www.ncbi.nlm.nih.gov/pubmed/31609483 http://dx.doi.org/10.1002/chem.201904044 |