Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions

The highly strained cubane system is of great interest as a scaffold and rigid linker in both pharmaceutical and materials chemistry. The first electrochemical functionalisation of cubane by oxidative decarboxylative ether formation (Hofer–Moest reaction) was demonstrated. The mild conditions are co...

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Detalles Bibliográficos
Autores principales: Collin, Diego E., Folgueiras‐Amador, Ana A., Pletcher, Derek, Light, Mark E., Linclau, Bruno, Brown, Richard C. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973092/
https://www.ncbi.nlm.nih.gov/pubmed/31593312
http://dx.doi.org/10.1002/chem.201904479
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author Collin, Diego E.
Folgueiras‐Amador, Ana A.
Pletcher, Derek
Light, Mark E.
Linclau, Bruno
Brown, Richard C. D.
author_facet Collin, Diego E.
Folgueiras‐Amador, Ana A.
Pletcher, Derek
Light, Mark E.
Linclau, Bruno
Brown, Richard C. D.
author_sort Collin, Diego E.
collection PubMed
description The highly strained cubane system is of great interest as a scaffold and rigid linker in both pharmaceutical and materials chemistry. The first electrochemical functionalisation of cubane by oxidative decarboxylative ether formation (Hofer–Moest reaction) was demonstrated. The mild conditions are compatible with the presence of other oxidisable functional groups, and the use of flow electrochemical conditions allows straightforward upscaling.
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spelling pubmed-69730922020-01-27 Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions Collin, Diego E. Folgueiras‐Amador, Ana A. Pletcher, Derek Light, Mark E. Linclau, Bruno Brown, Richard C. D. Chemistry Communications The highly strained cubane system is of great interest as a scaffold and rigid linker in both pharmaceutical and materials chemistry. The first electrochemical functionalisation of cubane by oxidative decarboxylative ether formation (Hofer–Moest reaction) was demonstrated. The mild conditions are compatible with the presence of other oxidisable functional groups, and the use of flow electrochemical conditions allows straightforward upscaling. John Wiley and Sons Inc. 2019-11-07 2020-01-07 /pmc/articles/PMC6973092/ /pubmed/31593312 http://dx.doi.org/10.1002/chem.201904479 Text en © 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Collin, Diego E.
Folgueiras‐Amador, Ana A.
Pletcher, Derek
Light, Mark E.
Linclau, Bruno
Brown, Richard C. D.
Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions
title Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions
title_full Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions
title_fullStr Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions
title_full_unstemmed Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions
title_short Cubane Electrochemistry: Direct Conversion of Cubane Carboxylic Acids to Alkoxy Cubanes Using the Hofer–Moest Reaction under Flow Conditions
title_sort cubane electrochemistry: direct conversion of cubane carboxylic acids to alkoxy cubanes using the hofer–moest reaction under flow conditions
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973092/
https://www.ncbi.nlm.nih.gov/pubmed/31593312
http://dx.doi.org/10.1002/chem.201904479
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