Engineered C–N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners

Aspartic acid derivatives with branched N‐alkyl or N‐arylalkyl substituents are valuable precursors to artificial dipeptide sweeteners such as neotame and advantame. The development of a biocatalyst to synthesize these compounds in a single asymmetric step is an as yet unmet challenge. Reported here...

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Detalles Bibliográficos
Autores principales: Zhang, Jielin, Grandi, Eleonora, Fu, Haigen, Saravanan, Thangavelu, Bothof, Laura, Tepper, Pieter G., Thunnissen, Andy‐Mark W. H., Poelarends, Gerrit J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973171/
https://www.ncbi.nlm.nih.gov/pubmed/31625664
http://dx.doi.org/10.1002/anie.201910704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973171/
https://www.ncbi.nlm.nih.gov/pubmed/31625664
http://dx.doi.org/10.1002/anie.201910704

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