One‐Step Synthesis of 2,5‐Diaminoimidazoles and Total Synthesis of Methylglyoxal‐Derived Imidazolium Crosslink (MODIC)

Here we describe a general method for the synthesis of 2,5‐diaminoimidazoles, which involves a thermal reaction between α‐aminoketones and substituted guanylhydrazines without the need for additives. As one of the few known ways to access the 2,5‐diaminoimidazole motif, our method greatly expands th...

Descripción completa

Detalles Bibliográficos
Autores principales: Sabbasani, Venkata R., Wang, Kung‐Pern, Streeter, Matthew D., Spiegel, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973230/
https://www.ncbi.nlm.nih.gov/pubmed/31713976
http://dx.doi.org/10.1002/anie.201911156

Ejemplares similares

Ejemplares similares