Two common disease-associated TYK2 variants impact exon splicing and TYK2 dosage

TYK2 belongs to the JAK protein tyrosine kinase family and mediates signaling of numerous antiviral and immunoregulatory cytokines (type I and type III IFNs, IL-10, IL-12, IL-22, IL-23) in immune and non-immune cells. After many years of genetic association studies, TYK2 is recognized as a susceptib...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Zhi, Rotival, Maxime, Patin, Etienne, Michel, Frédérique, Pellegrini, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974145/
https://www.ncbi.nlm.nih.gov/pubmed/31961910
http://dx.doi.org/10.1371/journal.pone.0225289

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974145/
https://www.ncbi.nlm.nih.gov/pubmed/31961910
http://dx.doi.org/10.1371/journal.pone.0225289

Ejemplares similares