Cargando…
Catecholaminergic modulation of meta-learning
The remarkable expedience of human learning is thought to be underpinned by meta-learning, whereby slow accumulative learning processes are rapidly adjusted to the current learning environment. To date, the neurobiological implementation of meta-learning remains unclear. A burgeoning literature argu...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974360/ https://www.ncbi.nlm.nih.gov/pubmed/31850844 http://dx.doi.org/10.7554/eLife.51439 |
_version_ | 1783490081794818048 |
---|---|
author | Cook, Jennifer L Swart, Jennifer C Froböse, Monja I Diaconescu, Andreea O Geurts, Dirk EM den Ouden, Hanneke EM Cools, Roshan |
author_facet | Cook, Jennifer L Swart, Jennifer C Froböse, Monja I Diaconescu, Andreea O Geurts, Dirk EM den Ouden, Hanneke EM Cools, Roshan |
author_sort | Cook, Jennifer L |
collection | PubMed |
description | The remarkable expedience of human learning is thought to be underpinned by meta-learning, whereby slow accumulative learning processes are rapidly adjusted to the current learning environment. To date, the neurobiological implementation of meta-learning remains unclear. A burgeoning literature argues for an important role for the catecholamines dopamine and noradrenaline in meta-learning. Here, we tested the hypothesis that enhancing catecholamine function modulates the ability to optimise a meta-learning parameter (learning rate) as a function of environmental volatility. 102 participants completed a task which required learning in stable phases, where the probability of reinforcement was constant, and volatile phases, where probabilities changed every 10–30 trials. The catecholamine transporter blocker methylphenidate enhanced participants’ ability to adapt learning rate: Under methylphenidate, compared with placebo, participants exhibited higher learning rates in volatile relative to stable phases. Furthermore, this effect was significant only with respect to direct learning based on the participants’ own experience, there was no significant effect on inferred-value learning where stimulus values had to be inferred. These data demonstrate a causal link between catecholaminergic modulation and the adjustment of the meta-learning parameter learning rate. |
format | Online Article Text |
id | pubmed-6974360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-69743602020-01-23 Catecholaminergic modulation of meta-learning Cook, Jennifer L Swart, Jennifer C Froböse, Monja I Diaconescu, Andreea O Geurts, Dirk EM den Ouden, Hanneke EM Cools, Roshan eLife Neuroscience The remarkable expedience of human learning is thought to be underpinned by meta-learning, whereby slow accumulative learning processes are rapidly adjusted to the current learning environment. To date, the neurobiological implementation of meta-learning remains unclear. A burgeoning literature argues for an important role for the catecholamines dopamine and noradrenaline in meta-learning. Here, we tested the hypothesis that enhancing catecholamine function modulates the ability to optimise a meta-learning parameter (learning rate) as a function of environmental volatility. 102 participants completed a task which required learning in stable phases, where the probability of reinforcement was constant, and volatile phases, where probabilities changed every 10–30 trials. The catecholamine transporter blocker methylphenidate enhanced participants’ ability to adapt learning rate: Under methylphenidate, compared with placebo, participants exhibited higher learning rates in volatile relative to stable phases. Furthermore, this effect was significant only with respect to direct learning based on the participants’ own experience, there was no significant effect on inferred-value learning where stimulus values had to be inferred. These data demonstrate a causal link between catecholaminergic modulation and the adjustment of the meta-learning parameter learning rate. eLife Sciences Publications, Ltd 2019-12-18 /pmc/articles/PMC6974360/ /pubmed/31850844 http://dx.doi.org/10.7554/eLife.51439 Text en © 2019, Cook et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Cook, Jennifer L Swart, Jennifer C Froböse, Monja I Diaconescu, Andreea O Geurts, Dirk EM den Ouden, Hanneke EM Cools, Roshan Catecholaminergic modulation of meta-learning |
title | Catecholaminergic modulation of meta-learning |
title_full | Catecholaminergic modulation of meta-learning |
title_fullStr | Catecholaminergic modulation of meta-learning |
title_full_unstemmed | Catecholaminergic modulation of meta-learning |
title_short | Catecholaminergic modulation of meta-learning |
title_sort | catecholaminergic modulation of meta-learning |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974360/ https://www.ncbi.nlm.nih.gov/pubmed/31850844 http://dx.doi.org/10.7554/eLife.51439 |
work_keys_str_mv | AT cookjenniferl catecholaminergicmodulationofmetalearning AT swartjenniferc catecholaminergicmodulationofmetalearning AT frobosemonjai catecholaminergicmodulationofmetalearning AT diaconescuandreeao catecholaminergicmodulationofmetalearning AT geurtsdirkem catecholaminergicmodulationofmetalearning AT denoudenhannekeem catecholaminergicmodulationofmetalearning AT coolsroshan catecholaminergicmodulationofmetalearning |