Immunomodulatory Protective Effects of Rb9 Cyclic-Peptide in a Metastatic Melanoma Setting and the Involvement of Dendritic Cells

The cyclic VHCDR3-derived peptide (Rb9) from RebMab200 antibody, directed to a NaPi2B phosphate-transport protein, displayed anti-metastatic melanoma activity at 50–300 μg intraperitoneally injected in syngeneic mice. Immune deficient mice failed to respond to the peptide protective effect. Rb9 indu...

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Detalles Bibliográficos
Autores principales: Machado, Fabrício C., Girola, Natália, Maia, Vera S. C., Bergami-Santos, Patrícia C., Morais, Alice S., Azevedo, Ricardo A., Figueiredo, Carlos R., Barbuto, José A. M., Travassos, Luiz R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974543/
https://www.ncbi.nlm.nih.gov/pubmed/32010152
http://dx.doi.org/10.3389/fimmu.2019.03122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974543/
https://www.ncbi.nlm.nih.gov/pubmed/32010152
http://dx.doi.org/10.3389/fimmu.2019.03122

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