CRISPR Interference of a Clonally Variant GC-Rich Noncoding RNA Family Leads to General Repression of var Genes in Plasmodium falciparum

The human malaria parasite Plasmodium falciparum uses mutually exclusive expression of the PfEMP1-encoding var gene family to evade the host immune system. Despite progress in the molecular understanding of the default silencing mechanism, the activation mechanism of the uniquely expressed var membe...

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Detalles Bibliográficos
Autores principales: Barcons-Simon, Anna, Cordon-Obras, Carlos, Guizetti, Julien, Bryant, Jessica M., Scherf, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974570/
https://www.ncbi.nlm.nih.gov/pubmed/31964736
http://dx.doi.org/10.1128/mBio.03054-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974570/
https://www.ncbi.nlm.nih.gov/pubmed/31964736
http://dx.doi.org/10.1128/mBio.03054-19

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