Tau inhibits PKA by nuclear proteasome‐dependent PKAR2α elevation with suppressed CREB/GluA1 phosphorylation

Intraneuronal accumulation of wild‐type tau plays a key role in Alzheimer's disease, while the mechanisms underlying tauopathy and memory impairment remain unclear. Here, we report that overexpressing full‐length wild‐type human tau (hTau) in mouse hippocampus induces learning and memory defici...

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Detalles Bibliográficos
Autores principales: Ye, Jinwang, Yin, Yaling, Liu, Huanhuan, Fang, Lin, Tao, Xiaoqing, Wei, Linyu, Zuo, Yue, Yin, Ying, Ke, Dan, Wang, Jian‐Zhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974714/
https://www.ncbi.nlm.nih.gov/pubmed/31668016
http://dx.doi.org/10.1111/acel.13055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974714/
https://www.ncbi.nlm.nih.gov/pubmed/31668016
http://dx.doi.org/10.1111/acel.13055

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