The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy

The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded polyglutamine repeats. The physiological role of this deubiquitylase, however, remains largely unclear. Our recent work showed that...

Descripción completa

Detalles Bibliográficos
Autores principales: Herzog, Laura K., Kevei, Éva, Marchante, Ricardo, Böttcher, Claudia, Bindesbøll, Christian, Lystad, Alf Håkon, Pfeiffer, Annika, Gierisch, Maria E., Salomons, Florian A., Simonsen, Anne, Hoppe, Thorsten, Dantuma, Nico P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974715/
https://www.ncbi.nlm.nih.gov/pubmed/31625269
http://dx.doi.org/10.1111/acel.13051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974715/
https://www.ncbi.nlm.nih.gov/pubmed/31625269
http://dx.doi.org/10.1111/acel.13051

Ejemplares similares