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mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging
Cerebrovascular dysfunction and cognitive decline are highly prevalent in aging, but the mechanisms underlying these impairments are unclear. Cerebral blood flow decreases with aging and is one of the earliest events in the pathogenesis of Alzheimer's disease (AD). We have previously shown that...
Autores principales: | Van Skike, Candice E., Lin, Ai‐Ling, Roberts Burbank, Raquel, Halloran, Jonathan J., Hernandez, Stephen F., Cuvillier, James, Soto, Vanessa Y., Hussong, Stacy A., Jahrling, Jordan B., Javors, Martin A., Hart, Matthew J., Fischer, Kathleen E., Austad, Steven N., Galvan, Veronica |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974719/ https://www.ncbi.nlm.nih.gov/pubmed/31693798 http://dx.doi.org/10.1111/acel.13057 |
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