Decreased pericellular matrix production and selection for enhanced cell membrane repair may impair osteocyte responses to mechanical loading in the aging skeleton

Transient plasma membrane disruptions (PMD) occur in osteocytes with in vitro and in vivo loading, initiating mechanotransduction. The goal here was to determine whether osteocyte PMD formation or repair is affected by aging. Osteocytes from old (24 months) mice developed fewer PMD (−76% females, −5...

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Detalles Bibliográficos
Autores principales: Hagan, Mackenzie L., Yu, Kanglun, Zhu, Jiali, Vinson, Brooke N., Roberts, Rachel L., Montesinos Cartagena, Marlian, Johnson, Maribeth H., Wang, Liyun, Isales, Carlos M., Hamrick, Mark W., McNeil, Paul L., McGee‐Lawrence, Meghan E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974724/
https://www.ncbi.nlm.nih.gov/pubmed/31743583
http://dx.doi.org/10.1111/acel.13056

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974724/
https://www.ncbi.nlm.nih.gov/pubmed/31743583
http://dx.doi.org/10.1111/acel.13056

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