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Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, Spalax

The blind mole rat (Spalax) is a wild, long‐lived rodent that has evolved mechanisms to tolerate hypoxia and resist cancer. Previously, we demonstrated high DNA repair capacity and low DNA damage in Spalax fibroblasts following genotoxic stress compared with rats. Since the acquisition of senescence...

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Detalles Bibliográficos
Autores principales: Odeh, Amani, Dronina, Maria, Domankevich, Vered, Shams, Imad, Manov, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6974727/
https://www.ncbi.nlm.nih.gov/pubmed/31605433
http://dx.doi.org/10.1111/acel.13045