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Late clinical failure associated with cytochrome b codon 268 mutation during treatment of falciparum malaria with atovaquone–proguanil in traveller returning from Congo
BACKGROUND: The drug combination atovaquone–proguanil, is recommended for treatment of uncomplicated falciparum malaria in France. Despite high efficacy, atovaquone–proguanil treatment failures have been reported. Resistance to cycloguanil, the active metabolite of proguanil, is conferred by multipl...
Autores principales: | Massamba, Laurencie, Madamet, Marylin, Benoit, Nicolas, Chevalier, Alicia, Fonta, Isabelle, Mondain, Véronique, Jeandel, Pierre-Yves, Amalvict, Rémy, Delaunay, Pascal, Mosnier, Joel, Marty, Pierre, Pomares, Christelle, Pradines, Bruno |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975030/ https://www.ncbi.nlm.nih.gov/pubmed/31964401 http://dx.doi.org/10.1186/s12936-020-3126-y |
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