A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

BACKGROUND: The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP metabolism and Aβ formation, and its levels are reduced in...

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Detalles Bibliográficos
Autores principales: Li, Jian-Guo, Chiu, Jin, Ramanjulu, Mercy, Blass, Benjamin E., Praticò, Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975032/
https://www.ncbi.nlm.nih.gov/pubmed/31964406
http://dx.doi.org/10.1186/s13024-019-0350-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975032/
https://www.ncbi.nlm.nih.gov/pubmed/31964406
http://dx.doi.org/10.1186/s13024-019-0350-4

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