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A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles
BACKGROUND: The vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex system, an ubiquitous multiprotein assembly responsible for sorting and trafficking protein cargos out of the endosomes. VPS35 can regulate APP metabolism and Aβ formation, and its levels are reduced in...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975032/ https://www.ncbi.nlm.nih.gov/pubmed/31964406 http://dx.doi.org/10.1186/s13024-019-0350-4 |