Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab

BACKGROUND: Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structure. In vivo, animal cells are able to fold mAbs correctly (Song et al, J Biosci...

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Detalles Bibliográficos
Autores principales: Farràs, Mercè, Román, Ramón, Camps, Marc, Miret, Joan, Martínez, Óscar, Pujol, Xavier, Casablancas, Antoni, Cairó, Jordi Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975058/
https://www.ncbi.nlm.nih.gov/pubmed/31964343
http://dx.doi.org/10.1186/s12860-019-0244-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975058/
https://www.ncbi.nlm.nih.gov/pubmed/31964343
http://dx.doi.org/10.1186/s12860-019-0244-x

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