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Heavy chain dimers stabilized by disulfide bonds are required to promote in vitro assembly of trastuzumab
BACKGROUND: Monoclonal antibodies (mAbs) and their derivatives have become one of the most important classes of therapeutic drugs. Their multiple applications increased the interest for understanding their complex structure. In vivo, animal cells are able to fold mAbs correctly (Song et al, J Biosci...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975058/ https://www.ncbi.nlm.nih.gov/pubmed/31964343 http://dx.doi.org/10.1186/s12860-019-0244-x |