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Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration
How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We found that depleting neuronal lipin1, a key enzyme controlling the balanced synthesis of glycerolipids through the glycerol phosphate pathway, enhanced axon regeneration after optic nerve injury. Axotomy elevated l...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cell Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975164/ https://www.ncbi.nlm.nih.gov/pubmed/31786011 http://dx.doi.org/10.1016/j.neuron.2019.10.009 |