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Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration

How adult neurons coordinate lipid metabolism to regenerate axons remains elusive. We found that depleting neuronal lipin1, a key enzyme controlling the balanced synthesis of glycerolipids through the glycerol phosphate pathway, enhanced axon regeneration after optic nerve injury. Axotomy elevated l...

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Detalles Bibliográficos
Autores principales:	Yang, Chao, Wang, Xu, Wang, Jianying, Wang, Xuejie, Chen, Weitao, Lu, Na, Siniossoglou, Symeon, Yao, Zhongping, Liu, Kai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975164/ https://www.ncbi.nlm.nih.gov/pubmed/31786011 http://dx.doi.org/10.1016/j.neuron.2019.10.009

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