Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production

Chinese hamster ovary (CHO) cell expression systems have been exquisitely developed for the production of recombinant biotherapeutics (e.g. standard monoclonal antibodies, mAbs) and are able to generate efficacious, multi-domain proteins with human-like post translational modifications at high conce...

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Detalles Bibliográficos
Autores principales: Budge, James D., Knight, Tanya J., Povey, Jane, Roobol, Joanne, Brown, Ian R., Singh, Gurdeep, Dean, Andrew, Turner, Sarah, Jaques, Colin M., Young, Robert J., Racher, Andrew J., Smales, C. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975165/
https://www.ncbi.nlm.nih.gov/pubmed/31805379
http://dx.doi.org/10.1016/j.ymben.2019.11.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975165/
https://www.ncbi.nlm.nih.gov/pubmed/31805379
http://dx.doi.org/10.1016/j.ymben.2019.11.007

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