Cargando…

USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA

Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING) senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA virus infection and activates innate antiviral immune response. It has been demonstrated that the activity of MITA is delicately re...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Hong-Yan, Liao, Bo-Wei, Xu, Zhi-Sheng, Ran, Yong, Wang, Dong-Peng, Yang, Yan, Luo, Wei-Wei, Wang, Yan-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975528/ https://www.ncbi.nlm.nih.gov/pubmed/31968013 http://dx.doi.org/10.1371/journal.ppat.1008178

Ejemplares similares

MITA/STING: A central and multifaceted mediator in innate immune response
por: Ran, Yong, et al.
Publicado: (2014)

SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA
por: Wei, Jin, et al.
Publicado: (2018)

Dengue Virus Targets the Adaptor Protein MITA to Subvert Host Innate Immunity
por: Yu, Chia-Yi, et al.
Publicado: (2012)

Human cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response
por: Fu, Yu-Zhi, et al.
Publicado: (2019)

Deubiquitination and stabilization of PTEN by USP13
por: Zhang, Jinsong, et al.
Publicado: (2013)

USP19 deubiquitinates HDAC1/2 to regulate DNA damage repair and control chromosomal stability
por: Wu, Min, et al.
Publicado: (2016)

USP10 deubiquitinates Tau, mediating its aggregation
por: Wei, Zhen, et al.
Publicado: (2022)

RNF115 plays dual roles in innate antiviral responses by catalyzing distinct ubiquitination of MAVS and MITA
por: Zhang, Zhi-Dong, et al.
Publicado: (2020)

USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
por: Ye, Liya, et al.
Publicado: (2019)

USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM
por: Wu, Chenming, et al.
Publicado: (2021)

USP21 modulates Goosecoid function through deubiquitination
por: Liu, Fuwei, et al.
Publicado: (2019)

USP13 negatively regulates antiviral responses by deubiquitinating STING
por: Sun, He, et al.
Publicado: (2017)

USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/β‐catenin pathway via Axin1 deubiquitination
por: Huang, Tong, et al.
Publicado: (2020)

Deubiquitinating enzyme USP10 promotes hepatocellular carcinoma metastasis through deubiquitinating and stabilizing Smad4 protein
por: Yuan, Tao, et al.
Publicado: (2019)

Evolution of the highly networked deubiquitinating enzymes USP4, USP15, and USP11
por: Vlasschaert, Caitlyn, et al.
Publicado: (2015)

Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
por: Sun, Xiaohan, et al.
Publicado: (2019)

The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity
por: Zong, Zhi, et al.
Publicado: (2020)

The RNA-binding protein LUC7L2 mediates MITA/STING intron retention to negatively regulate innate antiviral response
por: Li, Chen, et al.
Publicado: (2021)

Deubiquitinating enzyme USP30 negatively regulates mitophagy and accelerates myocardial cell senescence through antagonism of Parkin
por: Pan, Wei, et al.
Publicado: (2021)

Inhibition of USP14 Deubiquitinating Activity as a Potential Therapy for Tumors with p53 Deficiency
por: Ma, Yu-Shui, et al.
Publicado: (2020)

USP17 Suppresses Tumorigenesis and Tumor Growth through Deubiquitinating AEP
por: Chen, Xi, et al.
Publicado: (2019)

Regulation and function of the cGAS-MITA/STING axis in health and disease
por: Zhang, Zhi-Dong, et al.
Publicado: (2022)

USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer: USP14 deubiquitinates CDK1 in breast cancer
por: Liu, Yuhan, et al.
Publicado: (2022)

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity
por: Gersch, Malte, et al.
Publicado: (2019)

Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface
por: Liu, Jun, et al.
Publicado: (2023)

The role of the deubiquitinating enzyme DUB3/USP17 in cancer: a narrative review
por: Yang, Guang-Fei, et al.
Publicado: (2021)

The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ
por: Li, Jin, et al.
Publicado: (2022)

Regulation of XPC deubiquitination by USP11 in repair of UV-induced DNA damage
por: Shah, Palak, et al.
Publicado: (2017)

USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses
por: Zhang, Na, et al.
Publicado: (2022)

USP13 promotes deubiquitination of ZHX2 and tumorigenesis in kidney cancer
por: Xie, Haibiao, et al.
Publicado: (2022)

Deubiquitination of Dishevelled by Usp14 is required for Wnt signaling
por: Jung, H, et al.
Publicado: (2013)

Deubiquitination in prostate cancer progression: role of USP22
por: Nag, Nivedita, et al.
Publicado: (2020)

USP8 maintains embryonic stem cell stemness via deubiquitination of EPG5
por: Gu, Haifeng, et al.
Publicado: (2019)

Identifying USPs regulating immune signals in Drosophila: USP2 deubiquitinates Imd and promotes its degradation by interacting with the proteasome
por: Engel, Elodie, et al.
Publicado: (2014)

USP11 mediates repair of DNA–protein cross-links by deubiquitinating SPRTN metalloprotease
por: Perry, Megan, et al.
Publicado: (2021)

Correction to ‘USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM’
Publicado: (2023)

USP12 promotes antiviral responses by deubiquitinating and stabilizing IFI16
por: Fu, Yuling, et al.
Publicado: (2023)

The deubiquitinating enzyme USP1 modulates ERα and modulates breast cancer progression
por: Niu, Zhiguo, et al.
Publicado: (2020)

Structural Basis of Ubiquitin Recognition by the Deubiquitinating Protease USP2
por: Renatus, Martin, et al.
Publicado: (2006)

USP37 Deubiquitinates CDC73 in HPT-JT Syndrome
por: Kim, Su Yeon, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kr2ljegv17vesgd7inf1rm5nk7