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Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP(3) receptor
Inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) is a huge tetrameric intracellular Ca(2+) channel that mediates cytoplasmic Ca(2+) signaling. The structural basis of the gating in IP(3)R has been studied by X-ray crystallography and cryo-electron microscopy, focusing on the domain rearrangeme...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Biophysical Society of Japan (BSJ)
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975907/ https://www.ncbi.nlm.nih.gov/pubmed/31984176 http://dx.doi.org/10.2142/biophysico.16.0_232 |