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Allosteric response to ligand binding: Molecular dynamics study of the N-terminal domains in IP(3) receptor

Inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) is a huge tetrameric intracellular Ca(2+) channel that mediates cytoplasmic Ca(2+) signaling. The structural basis of the gating in IP(3)R has been studied by X-ray crystallography and cryo-electron microscopy, focusing on the domain rearrangeme...

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Detalles Bibliográficos
Autores principales:	Moritsugu, Kei, Ito, Tsubasa, Kidera, Akinori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Biophysical Society of Japan (BSJ) 2019
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975907/ https://www.ncbi.nlm.nih.gov/pubmed/31984176 http://dx.doi.org/10.2142/biophysico.16.0_232

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