Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease

The degeneration of cholinergic neurons is a prominent feature of Alzheimer’s disease (AD). In animal models of injury and aging, nerve growth factor (NGF) enhances cholinergic cell survival and function, contributing to improved memory. In the presence of AD pathology, however, NGF-related therapeu...

Descripción completa

Detalles Bibliográficos
Autores principales: Xhima, K., Markham-Coultes, K., Nedev, H., Heinen, S., Saragovi, H. U., Hynynen, K., Aubert, I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976301/
https://www.ncbi.nlm.nih.gov/pubmed/32010781
http://dx.doi.org/10.1126/sciadv.aax6646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976301/
https://www.ncbi.nlm.nih.gov/pubmed/32010781
http://dx.doi.org/10.1126/sciadv.aax6646

Ejemplares similares