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Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model

The poor diffusion of intravenous antibiotics in lung tissue makes nosocomial pneumonia challenging to treat, notably in critical patients under mechanical ventilation. The combination of ultrasound and microbubbles (USMB) is an emerging method for non-invasive and targeted enhancement of uptake of...

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Autores principales: Espitalier, Fabien, Darrouzain, François, Escoffre, Jean-Michel, Ternant, David, Piver, Eric, Bouakaz, Ayache, Remerand, Francis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976529/
https://www.ncbi.nlm.nih.gov/pubmed/32009963
http://dx.doi.org/10.3389/fphar.2019.01562
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author Espitalier, Fabien
Darrouzain, François
Escoffre, Jean-Michel
Ternant, David
Piver, Eric
Bouakaz, Ayache
Remerand, Francis
author_facet Espitalier, Fabien
Darrouzain, François
Escoffre, Jean-Michel
Ternant, David
Piver, Eric
Bouakaz, Ayache
Remerand, Francis
author_sort Espitalier, Fabien
collection PubMed
description The poor diffusion of intravenous antibiotics in lung tissue makes nosocomial pneumonia challenging to treat, notably in critical patients under mechanical ventilation. The combination of ultrasound and microbubbles (USMB) is an emerging method for non-invasive and targeted enhancement of uptake of various drugs in several organs. This study aims to evaluate if USMB may increase amikacin concentration in condensed lung tissues in a mechanically ventilated rabbit model. When applied 60 or 160 min after the beginning of an intravenous amikacin infusion, USMB increased amikacin concentration in the condensed lung tissue by 1.33 (p = 0.025) or 1.56-fold (p = 0.028) respectively. When applied 70 min after the beginning of an intravenous amikacin infusion, USMB increased amikacin concentration in the muscle tissue by 2.52 (p = 0.025). In conclusion, this study demonstrates that USMB is a promising method for the targeted delivery of amikacin in mechanically ventilated condensed lung, thus opening new therapeutic fields against lung infections.
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spelling pubmed-69765292020-02-01 Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model Espitalier, Fabien Darrouzain, François Escoffre, Jean-Michel Ternant, David Piver, Eric Bouakaz, Ayache Remerand, Francis Front Pharmacol Pharmacology The poor diffusion of intravenous antibiotics in lung tissue makes nosocomial pneumonia challenging to treat, notably in critical patients under mechanical ventilation. The combination of ultrasound and microbubbles (USMB) is an emerging method for non-invasive and targeted enhancement of uptake of various drugs in several organs. This study aims to evaluate if USMB may increase amikacin concentration in condensed lung tissues in a mechanically ventilated rabbit model. When applied 60 or 160 min after the beginning of an intravenous amikacin infusion, USMB increased amikacin concentration in the condensed lung tissue by 1.33 (p = 0.025) or 1.56-fold (p = 0.028) respectively. When applied 70 min after the beginning of an intravenous amikacin infusion, USMB increased amikacin concentration in the muscle tissue by 2.52 (p = 0.025). In conclusion, this study demonstrates that USMB is a promising method for the targeted delivery of amikacin in mechanically ventilated condensed lung, thus opening new therapeutic fields against lung infections. Frontiers Media S.A. 2020-01-16 /pmc/articles/PMC6976529/ /pubmed/32009963 http://dx.doi.org/10.3389/fphar.2019.01562 Text en Copyright © 2020 Espitalier, Darrouzain, Escoffre, Ternant, Piver, Bouakaz and Remerand http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Espitalier, Fabien
Darrouzain, François
Escoffre, Jean-Michel
Ternant, David
Piver, Eric
Bouakaz, Ayache
Remerand, Francis
Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model
title Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model
title_full Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model
title_fullStr Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model
title_full_unstemmed Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model
title_short Enhanced Amikacin Diffusion With Ultrasound and Microbubbles in a Mechanically Ventilated Condensed Lung Rabbit Model
title_sort enhanced amikacin diffusion with ultrasound and microbubbles in a mechanically ventilated condensed lung rabbit model
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976529/
https://www.ncbi.nlm.nih.gov/pubmed/32009963
http://dx.doi.org/10.3389/fphar.2019.01562
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