VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake

Type 2 diabetes mellitus (T2DM) affects millions of people and is linked with obesity and lipid accumulation in peripheral tissues. Increased lipid handling and lipotoxicity in insulin producing β-cells may contribute to β-cell dysfunction in T2DM. The vascular endothelial growth factor (VEGF)-B reg...

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Detalles Bibliográficos
Autores principales: Ning, Frank Chenfei, Jensen, Nina, Mi, Jiarui, Lindström, William, Balan, Mirela, Muhl, Lars, Eriksson, Ulf, Nilsson, Ingrid, Nyqvist, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976647/
https://www.ncbi.nlm.nih.gov/pubmed/31969592
http://dx.doi.org/10.1038/s41598-020-57599-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976647/
https://www.ncbi.nlm.nih.gov/pubmed/31969592
http://dx.doi.org/10.1038/s41598-020-57599-2

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