Cargando…

VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake

Type 2 diabetes mellitus (T2DM) affects millions of people and is linked with obesity and lipid accumulation in peripheral tissues. Increased lipid handling and lipotoxicity in insulin producing β-cells may contribute to β-cell dysfunction in T2DM. The vascular endothelial growth factor (VEGF)-B reg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ning, Frank Chenfei, Jensen, Nina, Mi, Jiarui, Lindström, William, Balan, Mirela, Muhl, Lars, Eriksson, Ulf, Nilsson, Ingrid, Nyqvist, Daniel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976647/ https://www.ncbi.nlm.nih.gov/pubmed/31969592 http://dx.doi.org/10.1038/s41598-020-57599-2

Ejemplares similares

Noninvasive intravital high-resolution imaging of pancreatic neuroendocrine tumours
por: Balan, Mirela, et al.
Publicado: (2019)

VEGF‐B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content
por: Moessinger, Christine, et al.
Publicado: (2020)

Islets and Glucose Homeostasis
por: Chang, Tien-Jyun, et al.
Publicado: (2015)

Islet cilia and glucose homeostasis
por: Melena, Isabella, et al.
Publicado: (2022)

Immune regulation of islet homeostasis and adaptation
por: Guo, Jinglong, et al.
Publicado: (2020)

Intra-islet lesions and lobular variations in β-cell mass expansion in ob/ob mice revealed by 3D imaging of intact pancreas
por: Parween, Saba, et al.
Publicado: (2016)

Donor Islet Endothelial Cells in Pancreatic Islet Revascularization
por: Nyqvist, Daniel, et al.
Publicado: (2011)

Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC(hum) mice
por: Zeitelhofer, Manuel, et al.
Publicado: (2018)

Special Issue: Islet Inflammation and Metabolic Homeostasis
por: Burke, Susan J., et al.
Publicado: (2021)

Modulation of endoglin expression in islets of langerhans by VEGF reveals a novel regulator of islet endothelial cell function
por: Clarkin, Claire E., et al.
Publicado: (2016)

Intra-islet glucagon secretion and action in the regulation of glucose homeostasis
por: Wang, Qinghua, et al.
Publicado: (2013)

A protocol for studying glucose homeostasis and islet function in mice
por: Al Rijjal, Dana, et al.
Publicado: (2022)

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling
por: Xiong, Yan, et al.
Publicado: (2020)

Renal Involvement in Preeclampsia: Similarities to VEGF Ablation Therapy
por: Müller-Deile, Janina, et al.
Publicado: (2011)

MafA Expression Preserves Immune Homeostasis in Human and Mouse Islets
por: Singh, Tania, et al.
Publicado: (2018)

Primary cilia control glucose homeostasis via islet paracrine interactions
por: Hughes, Jing W., et al.
Publicado: (2020)

VEGF Upregulation in Viral Infections and Its Possible Therapeutic Implications
por: Alkharsah, Khaled R.
Publicado: (2018)

VEGF promotes gastric cancer development by upregulating CRMP4
por: Chen, Sile, et al.
Publicado: (2016)

The splicing factor YBX1 promotes the progression of osteosarcoma by upregulating VEGF(165) and downregulating VEGF(165b)
por: Quan, Bingxuan, et al.
Publicado: (2023)

Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood–brain barrier
por: Zeitelhofer, Manuel, et al.
Publicado: (2020)

Vagotomy ameliorates islet morphofunction and body metabolic homeostasis in MSG-obese rats
por: Lubaczeuski, C., et al.
Publicado: (2015)

The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
por: Backe, Marie Balslev, et al.
Publicado: (2019)

Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature
por: Ceasrine, Alexis M, et al.
Publicado: (2018)

Crosstalk between Macrophages and Pancreatic β-Cells in Islet Development, Homeostasis and Disease
por: Cosentino, Cristina, et al.
Publicado: (2021)

Artemether treatment improves islet function and metabolic homeostasis in diabetic nonhuman primates
por: Fu, Wei, et al.
Publicado: (2023)

Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1(+) Macrophage Infiltration
por: Wada, Iori, et al.
Publicado: (2021)

ZEB1 Upregulates VEGF Expression and Stimulates Angiogenesis in Breast Cancer
por: Liu, Lingjia, et al.
Publicado: (2016)

Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells
por: Liu, Fuhong, et al.
Publicado: (2015)

Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors
por: Takeda, Takaaki, et al.
Publicado: (2012)

Uptake of the glycosphingolipid sulfatide in the gastrointestinal tract and pancreas in vivo and in isolated islets of Langerhans
por: Blomqvist, Maria, et al.
Publicado: (2006)

Preparatory studies of composite mesenchymal stem cell islets for application in intraportal islet transplantation
por: Duprez, Ida Rasmusson, et al.
Publicado: (2011)

Islet amyloid deposits preferentially in the highly functional and most blood-perfused islets
por: Ullsten, Sara, et al.
Publicado: (2017)

Pericyte Control of Blood Flow in Intraocular Islet Grafts Impacts Glucose Homeostasis in Mice
por: Tamayo, Alejandro, et al.
Publicado: (2022)

Brain homeostasis: VEGF receptor 1 and 2—two unequal brothers in mind
por: Wittko-Schneider, Ina M., et al.
Publicado: (2013)

Cyclic strain upregulates VEGF and attenuates proliferation of vascular smooth muscle cells
por: Schad, Joseph F, et al.
Publicado: (2011)

All-trans retinoic acid upregulates VEGF expression in glioma cells in vitro
por: Liang, Chen, et al.
Publicado: (2013)

Epigenetic Upregulation of Endogenous VEGF-A Reduces Myocardial Infarct Size in Mice
por: Turunen, Mikko P., et al.
Publicado: (2014)

Linking VEGF Deficiency and IL-33 Upregulation in Chronic Obstructive Pulmonary Disease
por: Byers, Derek E.
Publicado: (2019)

Glomerular Endothelial Cell-Derived miR-200c Impairs Glomerular Homeostasis by Targeting Podocyte VEGF-A
por: Ursu, Raluca, et al.
Publicado: (2022)

HIF-1 mediated upregulation of VEGF and VEGF-R in systemic sclerosis (SSc): Imbalance with angiostatic factors suggests VEGF as a novel option for the treatment of ischemia in patients with SSc
por: Distler, O, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_rttmadccq9u9hndeee7pp2cp40