Cargando…

Glucocorticoid induces human beta cell dysfunction by involving riborepressor GAS5 LincRNA

OBJECTIVE: A widely recognized metabolic side effect of glucocorticoid (GC) therapy is steroid-induced diabetes mellitus (DM). However, studies on the molecular basis of GC-induced pancreatic beta cell dysfunction in human beta cells are lacking. The significance of non-coding RNAs in various cellul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Esguerra, Jonathan L.S., Ofori, Jones K., Nagao, Mototsugu, Shuto, Yuki, Karagiannopoulos, Alexandros, Fadista, Joao, Sugihara, Hitoshi, Groop, Leif, Eliasson, Lena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Brief Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976904/ https://www.ncbi.nlm.nih.gov/pubmed/32029226 http://dx.doi.org/10.1016/j.molmet.2019.12.012

Ejemplares similares

Glucocorticoid-mediated induction of ZBTB16 affects insulin secretion in human islets and EndoC-βH1 β-cells
por: Karagiannopoulos, Alexandros, et al.
Publicado: (2023)

Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells
por: Nagao, Mototsugu, et al.
Publicado: (2020)

Human pancreatic islet miRNA-mRNA networks of altered miRNAs due to glycemic status
por: Karagiannopoulos, Alexandros, et al.
Publicado: (2022)

The highly expressed calcium‐insensitive synaptotagmin‐11 and synaptotagmin‐13 modulate insulin secretion
por: Ofori, Jones K., et al.
Publicado: (2022)

Comparative analysis of lincRNA in insect species
por: Lopez-Ezquerra, Alberto, et al.
Publicado: (2017)

Overexpression of the GR Riborepressor LncRNA GAS5 Results in Poor Treatment Response and Early Relapse in Childhood B-ALL
por: Xagorari, Marieta, et al.
Publicado: (2021)

miRNAs in the Beta Cell—Friends or Foes?
por: Karagiannopoulos, Alexandros, et al.
Publicado: (2023)

Chromatin Landscape Distinguishes the Genomic Loci of Hundreds of Androgen-Receptor-Associated LincRNAs From the Loci of Non-associated LincRNAs
por: daSilva, Lucas F., et al.
Publicado: (2018)

DiseaseLinc: Disease Enrichment Analysis of Sets of Differentially Expressed LincRNAs
por: More, Piyush, et al.
Publicado: (2021)

Repetitive Glucose Spikes Accelerate Atherosclerotic Lesion Formation in C57BL/6 Mice
por: Shuto, Yuki, et al.
Publicado: (2015)

lincRNAs act in the circuitry controlling pluripotency and differentiation
por: Guttman, Mitchell, et al.
Publicado: (2011)

HOXs and lincRNAs: Two sides of the same coin
por: De Kumar, Bony, et al.
Publicado: (2016)

The conservation and signatures of lincRNAs in Marek’s disease of chicken
por: He, Yanghua, et al.
Publicado: (2015)

LincRNA-p21: Implications in Human Diseases
por: Tang, Sai-Sai, et al.
Publicado: (2015)

The evolutionary landscape and expression pattern of plant lincRNAs
por: Chen, Li, et al.
Publicado: (2022)

Placental circadian lincRNAs and spontaneous preterm birth
por: Zhou, Guoli, et al.
Publicado: (2023)

MicroRNA Networks in Pancreatic Islet Cells: Normal Function and Type 2 Diabetes
por: Eliasson, Lena, et al.
Publicado: (2020)

Lionheart LincRNA alleviates cardiac systolic dysfunction under pressure overload
por: Kuwabara, Yasuhide, et al.
Publicado: (2020)

Corrigendum: The conservation and signatures of lincRNAs in Marek’s disease of chicken
por: He, Yanghua, et al.
Publicado: (2016)

Expression and regulation of lincRNAs during T cell development and differentiation
por: Hu, Gangqing, et al.
Publicado: (2013)

Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs
por: Schlackow, Margarita, et al.
Publicado: (2017)

Splicing of enhancer-associated lincRNAs contributes to enhancer activity
por: Tan, Jennifer Y, et al.
Publicado: (2020)

Male-specific roles of lincRNA in C. elegans fertility
por: Shabtai, Reut, et al.
Publicado: (2023)

Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell
por: Ofori, Jones K., et al.
Publicado: (2017)

LincRNA landscape in human lymphocytes highlights regulation of T cell differentiation by linc-MAF-4
por: Ranzani, Valeria, et al.
Publicado: (2015)

Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR
por: Leask, Megan, et al.
Publicado: (2019)

MiRNAs and LincRNAs: Could They Be Considered as Biomarkers in Colorectal Cancer?
por: Zarate, Ruth, et al.
Publicado: (2012)

Neurodevelopmental LincRNA Microsyteny Conservation and Mammalian Brain Size Evolution
por: Lewitus, Eric, et al.
Publicado: (2015)

Computational identification of putative lincRNAs in mouse embryonic stem cell
por: Liu, Hui, et al.
Publicado: (2016)

Decreased FENDRR and LincRNA-p21 expression in atherosclerotic plaque
por: Çekin, Nilgün, et al.
Publicado: (2018)

Identification of transcribed protein coding sequence remnants within lincRNAs
por: Talyan, Sweta, et al.
Publicado: (2018)

Enhancers in the Peril lincRNA locus regulate distant but not local genes
por: Groff, Abigail F., et al.
Publicado: (2018)

Systematic evaluation of C. elegans lincRNAs with CRISPR knockout mutants
por: Wei, Shuai, et al.
Publicado: (2019)

Global and cell-type specific properties of lincRNAs with ribosome occupancy
por: Wang, Hongwei, et al.
Publicado: (2017)

Novel lincRNA SLINKY is a prognostic biomarker in kidney cancer
por: Gong, Xue, et al.
Publicado: (2017)

EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas
por: Nowicki-Osuch, Karol, et al.
Publicado: (2017)

An evolutionarily conserved RNA structure in the functional core of the lincRNA Cyrano
por: Jones, Alisha N., et al.
Publicado: (2020)

Sperm Originated Chromatin Imprints and LincRNAs in Organismal Development and Cancer
por: Subhash, Santhilal, et al.
Publicado: (2020)

The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer
por: Wang, Hao, et al.
Publicado: (2023)

SNP@lincTFBS: An Integrated Database of Polymorphisms in Human LincRNA Transcription Factor Binding Sites
por: Ning, Shangwei, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_a8dkti0eb3d9ih5esaa9ulba5b