Codon optimization is an essential parameter for the efficient allotopic expression of mtDNA genes()

Mutations in mitochondrial DNA can be inherited or occur de novo leading to several debilitating myopathies with no curative option and few or no effective treatments. Allotopic expression of recoded mitochondrial genes from the nucleus has potential as a gene therapy strategy for such conditions, h...

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Detalles Bibliográficos
Autores principales: Lewis, Caitlin J., Dixit, Bhavna, Batiuk, Elizabeth, Hall, Carter J., O'Connor, Matthew S., Boominathan, Amutha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976934/
https://www.ncbi.nlm.nih.gov/pubmed/31981894
http://dx.doi.org/10.1016/j.redox.2020.101429

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976934/
https://www.ncbi.nlm.nih.gov/pubmed/31981894
http://dx.doi.org/10.1016/j.redox.2020.101429

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