The 3ʹ-untranslated region contributes to the pregnane X receptor (PXR) expression down-regulation by PXR ligands and up-regulation by glucocorticoids

Pregnane X receptor (PXR) is the major regulator of xenobiotic metabolism. PXR itself is controlled by various signaling molecules including glucocorticoids. Moreover, negative feed-back regulation has been proposed at the transcriptional level. We examined the involvement of the 3′-untranslated reg...

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Detalles Bibliográficos
Autores principales: Smutny, Tomas, Dusek, Jan, Hyrsova, Lucie, Nekvindova, Jana, Horvatova, Alzbeta, Micuda, Stanislav, Gerbal-Chaloin, Sabine, Pavek, Petr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976988/
https://www.ncbi.nlm.nih.gov/pubmed/31998607
http://dx.doi.org/10.1016/j.apsb.2019.09.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976988/
https://www.ncbi.nlm.nih.gov/pubmed/31998607
http://dx.doi.org/10.1016/j.apsb.2019.09.010

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