Hepatic and intestinal biotransformation gene expression and drug disposition in a dextran sulfate sodium-induced colitis mouse model

We examined the impact of gut inflammation on the expression of cytochrome P450 (P450) and other biotransformation genes in male mice using a dextran sulfate sodium (DSS)-induced colitis model. Several P450 isoforms, including CYP1A, CYP2B, CYP2C, and CYP3A, were down-regulated, accompanied by decre...

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Detalles Bibliográficos
Autores principales: Fan, Xiaoyu, Ding, Xinxin, Zhang, Qing-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976992/
https://www.ncbi.nlm.nih.gov/pubmed/31993311
http://dx.doi.org/10.1016/j.apsb.2019.12.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6976992/
https://www.ncbi.nlm.nih.gov/pubmed/31993311
http://dx.doi.org/10.1016/j.apsb.2019.12.002

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